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Version: 17.06d (Release date: 2017-06-26)
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Mapatumumab (Code C61502)

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Terms & Properties

Preferred Name: Mapatumumab

Definition: A fully human agonistic monoclonal antibody to tumor necrosis factor-related apoptosis-inducing ligand receptor-1 (TRAIL-R1) with apoptosis promoting and potential antitumor activities. TRAIL-R1 is a cell surface receptor expressed on many malignant cell types. Mapatumumab selectively binds to and activates the TRAIL cell receptor, thereby inducing apoptosis and reducing tumor growth.

NCI-GLOSS Definition: A substance being studied in the treatment of some types of cancer. It binds to a protein called TRAIL R1 on the surface of some tumor cells. This may kill the tumor cells. Anti-TRAIL R1-mAb is a type of monoclonal antibody.

Display Name: Mapatumumab

Label: Mapatumumab

NCI Thesaurus Code: C61502 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C1665688  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
anti-TRAIL R1-mAb
Anti-TRAIL R1-mAb
HGS-ETR1
Mapatumumab
TRM-1 mAb

External Source Codes: 
PDQ Closed Trial Search ID 486626
PDQ Open Trial Search ID 486626 (check for NCI PDQ open clinical trial info)
UMLS CUI C1665688

Other Properties:
     Name Value (qualifiers indented underneath)
code C61502
Contributing_Source CTRP
Legacy_Concept_Name Mapatumumab
Semantic_Type Amino Acid, Peptide, or Protein
Semantic_Type Immunologic Factor

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C61502

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