skip navigation links
National Cancer Institute
EVS Logo NCI Term Browser Enterprise Vocabulary Services
Terminologies Value Sets Mappings
Version: 17.06d (Release date: 2017-06-26)
SearchBox Top
SearchBox Bottom
Posaconazole (Code C61500)

Terms & Properties Synonym Details Relationships Mapping View All  
Terms & Properties

Preferred Name: Posaconazole

Definition: A broad-spectrum, second generation, triazole compound with antifungal activity. Posaconazole strongly inhibits 14-alpha demethylase, a cytochrome P450-dependent enzyme. Inhibition of 14-alpha-demethylase prevents the conversion of lanosterol to ergosterol, an important component of the fungal cell wall. Inhibition of ergosterol synthesis changes the fungal cell membrane composition and integrity, alters membrane permeability and eventually leads to fungal cell lysis. Compared to other azole antifungals, posaconazole is a significantly more potent inhibitor of sterol 14-alpha demethylase.

Display Name: Posaconazole

Label: Posaconazole

NCI Thesaurus Code: C61500 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0936148  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
SCH 56592

External Source Codes: 
CAS Registry Number 171228-49-2 (see NLM ChemIDplus info)
ChEBI ID CHEBI:64355 (see ChEBI info)
PDQ Closed Trial Search ID 361793
PDQ Open Trial Search ID 361793 (check for NCI PDQ open clinical trial info)
UMLS CUI C0936148

Other Properties:
     Name Value (qualifiers indented underneath)
Accepted_Therapeutic_Use_For Fungal Infection Prevention for Immunocompromised Host
Chemical_Formula C37H42F2N8O4
code C61500
Contributing_Source CTRP
Contributing_Source FDA
Legacy_Concept_Name Posaconazole
Semantic_Type Organic Chemical
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  


Mainbox Bottom