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Version: 17.12d (Release date: 2017-12-26)
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Nitric Oxide-Releasing Acetylsalicylic Acid Derivative (Code C61499)

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Terms & Properties

Preferred Name: Nitric Oxide-Releasing Acetylsalicylic Acid Derivative

Definition: A nitric oxide (NO) donating derivative of acetylsalicylic acid with anti-inflammatory, analgesic, antipyretic, antithrombotic, gastroprotective and potential antitumor activities. The acetylsalicylic acid derivative moiety of this agent inhibits the activities of cyclooxygenase (COX) I and II, preventing the formation of prostaglandins and thromboxanes. A reduction in prostaglandin synthesis accounts for this agent's anti-inflammatory, anti-pyretic and analgesic activities; a reduction in thromboxane A2 synthesis results in an irreversible inhibition of platelet aggregation. NO donation by this agent, after cleavage from the acetylsalicylic acid derivative in vivo, may protect the gastric mucosa against the damaging effects of the aspirin derivative by modulating prostaglandins. In tumor cells, the NO donating moiety may block the cell cycle in the G1 and G2 phases and may induce apoptosis through caspase-mediated mechanisms.

NCI-GLOSS Definition: A substance being studied in the prevention of colorectal cancer. It is a form of aspirin that gives off nitric oxide gas and is less irritating to the lining of the stomach than plain aspirin. It is a type of nonsteroidal anti-inflammatory drug (NSAID).

Label: Nitric Oxide-Releasing Acetylsalicylic Acid Derivative

NCI Thesaurus Code: C61499 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0531264  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Benzoic Acid, 2-(Acetyl-oxy)-3-[(nitrooxy)methyl]phenyl Ester
NCX 4016
nitric oxide-releasing acetylsalicylic acid derivative
Nitric Oxide-Releasing Acetylsalicylic Acid Derivative
Nitric Oxide-Releasing Aspirin Derivative

External Source Codes: 
PDQ Closed Trial Search ID 486415
PDQ Open Trial Search ID 486415 (check for NCI PDQ open clinical trial info)
UMLS CUI C0531264

Other Properties:
     Name Value (qualifiers indented underneath)
code C61499
Legacy_Concept_Name Nitric_Oxide-Releasing_Acetylsalicylic_Acid_Derivative
Semantic_Type Organic Chemical
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  


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