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Version: 17.06d (Release date: 2017-06-26)
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RFT5-dgA Immunotoxin (Code C61498)

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Terms & Properties

Preferred Name: RFT5-dgA Immunotoxin

Definition: A recombinant immunotoxin consisting of the anti-CD25 monoclonal antibody RFT5 fused to the deglycosylated ricin A-chain (dgA) with potential antitumor activity. The monoclonal antibody moiety of RFT5-dgA immunotoxin attaches to CD25 (the alpha chain of the IL-2 receptor complex) on the cell membrane; after internalization, the dgA moiety cleaves the N-glycosidic bond between the ribose and adenine base at position 4324 in 28S ribosomal RNA, resulting in ribosome inactivation, inhibition of protein synthesis, and cell death. CD25 is expressed on activated normal T and B cells and macrophages and is frequently upregulated in many hematologic malignancies.

NCI-GLOSS Definition: A monoclonal antibody linked to a toxic substance. It is being studied in the treatment of melanoma that has spread to distant parts of the body. IgG-RFT5-dgA is made in the laboratory. It can find and kill certain white blood cells that prevent the immune system from killing cancer cells.

Display Name: RFT5-dgA Immunotoxin

Label: RFT5-dgA Immunotoxin

NCI Thesaurus Code: C61498 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C1831838  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Anti-CD25 Immunotoxin IMTOX25
IgG-RFT5-dgA
IMTOX25
RFT5-dgA Immunotoxin
RFT5-dgA immunotoxin

External Source Codes: 
PDQ Closed Trial Search ID 486413
PDQ Open Trial Search ID 486413 (check for NCI PDQ open clinical trial info)
UMLS CUI C1831838

Other Properties:
     Name Value (qualifiers indented underneath)
code C61498
Contributing_Source CTRP
Legacy_Concept_Name RFT5-dgA_Immunotoxin
Semantic_Type Amino Acid, Peptide, or Protein
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C61498

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