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Version: 17.06d (Release date: 2017-06-26)
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TAS-108 (Code C61494)

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Terms & Properties

Preferred Name: TAS-108

Definition: A synthetic, antiestrogenic steroidal compound with potential antitumor activity. TAS-108 binds to and inhibits estrogenic receptor alpha (ERa), mainly expressed in the mammary gland and uterus and upregulated in estrogen-dependent tumors. Blockage of ERa by TAS-108 prevents the binding and effects of estrogen and may lead to an inhibition of estrogen-dependent cancer cell proliferation. TAS-108 also is a partial agonist of the estrogenic receptor beta (ERb), expressed in many tissues including the central nervous system, urogenital tract, bone and cardiovascular system, thereby exerting a positive effect on these tissues. In addition, TAS-108 activates the co-repressor Silencing Mediator for Retinoid and Thyroid hormone receptor (SMRT), a protein that inhibits the activities of the estrogen receptors, which may contribute to the antitumor activity of TAS-108.

Label: TAS-108

NCI Thesaurus Code: C61494 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C1435232  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
(7)-21-[4-[(diethylamino)methyl]-2-methoxyphenoxy]-7-methyl-19-norpregna-1,3,5(10)-trien-3-ol 2-hydroxy-1,2,3-propanetricarboxylate
SR 16234

External Source Codes: 
CAS Registry Number 354808-47-2 (see NLM ChemIDplus info)
PDQ Closed Trial Search ID 486347
PDQ Open Trial Search ID 486347 (check for NCI PDQ open clinical trial info)
UMLS CUI C1435232

Other Properties:
     Name Value (qualifiers indented underneath)
code C61494
Legacy_Concept_Name TAS-108
Semantic_Type Organic Chemical
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  


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