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Version: 17.06d (Release date: 2017-06-26)
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Adenovirus Encoding Recombinant Human Endostatin (Code C61492)

Terms & Properties Synonym Details Relationships Mapping View All  
Terms & Properties

Preferred Name: Adenovirus Encoding Recombinant Human Endostatin

Definition: A replication-defective, recombinant oncolytic adenovirus encoding human endostatin with potential antineoplastic activity. Endostatin, a 20 kDa C-terminal proteolytic fragment of collagen XVIII, is an important angiogenesis inhibitor. Upon intratumoral administration, the adenovirus infects and replicates in tumor cells. The expressed endostatin may inhibit endothelial cell proliferation and angiogenesis which may result in a reduction of tumor growth.

Display Name: Adenovirus Encoding Recombinant Human Endostatin

Label: Adenovirus Encoding Recombinant Human Endostatin

NCI Thesaurus Code: C61492 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C1831833  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Ad-rhENDO
Adenovirus Encoding Recombinant Human Endostatin
E10A

External Source Codes: 
PDQ Closed Trial Search ID 486329
PDQ Open Trial Search ID 486329 (check for NCI PDQ open clinical trial info)
UMLS CUI C1831833

Other Properties:
     Name Value (qualifiers indented underneath)
code C61492
Contributing_Source CTRP
Legacy_Concept_Name Adenovirus_Encoding_Recombinant_Human_Endostatin
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C61492

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