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Version: 16.11d (Release date: 2016-11-28)
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Darinaparsin (Code C61490)

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Terms & Properties

Preferred Name: Darinaparsin

Definition: A small-molecule organic arsenical with potential antineoplastic activity. Although the exact mechanism of action is unclear, darinaparsin, a highly toxic metabolic intermediate of inorganic arsenicals (iAs) that occurs in vivo, appears to generate volatile cytotoxic arsenic compounds when glutathione (GSH) concentrations are low. The arsenic compounds generated from darinaparsin disrupt mitochondrial bioenergetics, producing reactive oxygen species (ROS) and inducing ROS-mediated tumor cell apoptosis; in addition, this agent or its byproducts may initiate cell death by interrupting the G2/M phase of the cell cycle and may exhibit antiangiogenic effects. Compared to inorganic arsenic compounds such as arsenic trioxide (As2O3), darinaparsin appears to exhibit a wide therapeutic window.

Display Name: Darinaparsin

Label: Darinaparsin

NCI Thesaurus Code: C61490 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C1872686  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Darinaparsin
DARINAPARSIN
DMAIII(SG)
S-Dimethylarsino-Glutathione
ZIO-101

External Source Codes: 
CAS Registry Number 69819-86-9 (see NLM ChemIDplus info)
FDA UNII Code 9XX54M675G
PDQ Closed Trial Search ID 486305
PDQ Open Trial Search ID 486305 (check for NCI PDQ open clinical trial info)
UMLS CUI C1872686

Other Properties:
Name Value (qualifiers indented underneath)
Chemical_Formula C12H22AsN3O6S
code C61490
Contributing_Source CTRP
Contributing_Source FDA
Legacy_Concept_Name S-Dimethylarsino-Glutathione
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C61490

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