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Version: 16.11d (Release date: 2016-11-28)
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Terameprocol (Code C61441)

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Terms & Properties

Preferred Name: Terameprocol

Definition: A synthetic tetra-methylated derivative of nordihydroguaiaretic acid (NDGA) and transcriptional inhibitor with potential antiviral, antiangiogenic, and antineoplastic activities. Terameprocol competes with the transcription factor Sp1 for specific Sp1 DNA binding domains within gene promoter regions during DNA synthesis. In virally-infected cells, blocking of the Sp1 binding site suppresses Sp1-regulated viral promoter activity and gene expression, thereby inhibiting viral transcription and replication. In tumor cells, blockage of Sp1 binding sites by this agent interferes with the transcription of the Sp1-dependant genes cyclin-dependant kinase (Cdc2), survivin, and vascular endothelial growth factor (VEGF), which are overexpressed in a variety of cancers. By suppressing Sp1-regulated transcription of these genes, terameprocol may reduce tumor angiogenesis and tumor cell proliferation and induce tumor cell apoptosis.

NCI-GLOSS Definition: A substance being studied in the treatment of cancer. It blocks proteins needed for cancer growth. It is a type of transcriptional inhibitor.

Display Name: Terameprocol

Label: Terameprocol

NCI Thesaurus Code: C61441 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0654036  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
1,1'-(2,3-Dimethyl-1,4-butanediyl)bis(3,4-dimethoxybenzene)
EM-1421
M4N
Terameprocol
TERAMEPROCOL
Tetra-O-methyl-NDGA
tetra-O-methyl NDGA
Tetra-O-methyl Nordihydroguaiaretic Acid
tetra-O-methyl nordihydroguaiaretic acid
Tetramethoxynordihydroguaiaretic Acid
TMNDGA

External Source Codes: 
CAS Registry Number 24150-24-1 (see NLM ChemIDplus info)
FDA UNII Code 53YET703F2
NSC Code 136955 (see NCI DTP info)
PDQ Closed Trial Search ID 472205
PDQ Open Trial Search ID 472205 (check for NCI PDQ open clinical trial info)
UMLS CUI C0654036

Other Properties:
Name Value (qualifiers indented underneath)
Chemical_Formula C22H30O4
code C61441
Contributing_Source CTRP
Contributing_Source FDA
Legacy_Concept_Name EM-1421
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C61441

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