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National Cancer Institute
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Version: 17.12d (Release date: 2017-12-26)
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Transdermal Estrogen (Code C61440)

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Terms & Properties

Preferred Name: Transdermal Estrogen

Definition: A transdermal formulation containing the synthetic form of estradiol, the most potent, endogenously produced estrogen. Upon topical administration, estradiol diffuses through the cell membrane and binds to and activates specific intracellular estrogen receptors located on estrogen-responsive tissues, including the reproductive tract, breast, pituitary, hypothalamus, liver, and bone. The activated ligand-receptor complex binds to estrogen response elements on DNA and promotes the transcription of genes involved in the functioning of the female reproductive system and secondary sex characteristics. In addition, estradiol inhibits the pituitary secretion of the gonadotropins luteinizing hormone (LH) and follicle stimulating hormone (FSH) through a negative feedback mechanism.

Label: Transdermal Estrogen

NCI Thesaurus Code: C61440 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C1949350  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Estrodiol Gel
Transdermal Estrogen

External Source Codes: 
PDQ Closed Trial Search ID 472200
PDQ Open Trial Search ID 472200 (check for NCI PDQ open clinical trial info)
UMLS CUI C1949350

Other Properties:
     Name Value (qualifiers indented underneath)
code C61440
Legacy_Concept_Name Transdermal_Estrogen
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  


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