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Version: 17.12d (Release date: 2017-12-26)
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Pegylated Liposomal Belotecan (Code C61437)

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Terms & Properties

Preferred Name: Pegylated Liposomal Belotecan

Definition: A sterically stabilized, pegylated liposomal formulation containing belotecan, a semi-synthetic analogue of campthotecin with potential antitumor activity. Belotecan inhibits the action of topoisomerase I, an enzyme that produces reversible single-strand breaks in DNA during DNA replication. This agent stabilizes the topoisomerase I and DNA complex, resulting in the inhibition of religation of DNA breaks, inhibition of DNA replication, and apoptotic cell death. The polyethylene glycol coating allows for greater plasma circulation time, thus enhancing the concentration of belotecan at the tumor site. Encapsulation of belotecan preserves the active lactone form, resulting in an increased cytotoxic effect of belotecan.

Label: Pegylated Liposomal Belotecan

NCI Thesaurus Code: C61437 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C1831764  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Pegylated Liposomal Belotecan
STEALTH Liposomal Belotecan

External Source Codes: 
PDQ Closed Trial Search ID 471934
PDQ Open Trial Search ID 471934 (check for NCI PDQ open clinical trial info)
UMLS CUI C1831764

Other Properties:
     Name Value (qualifiers indented underneath)
code C61437
Legacy_Concept_Name S-CKD602
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  


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