|Licorice (Code C61436)|
|Terms & Properties|
Preferred Name: Licorice
Definition: An herbal extract derived from the root of the plant Glycyrrhiza glabra with potential anti-inflammatory, antioxidant, and antineoplastic activities. Licorice root extract contains glycoside glycyrrhizinic acid and numerous flavonoids. Glycyrrhizinic acid in licorice root extract is hydrolyzed to glycyrrhetic acid (GA); GA inhibits 11 beta-hydroxysteroid dehydrogenase, resulting in inhibition of the conversion of cortisol to the inactive steroid cortisone and elevated cortisol levels. In addition, GA inhibits 17,20-lyase and 17 beta-hydroxysteroid dehydrogenase, resulting in decreased conversions of 17-hydroxyprogesterone to androstenedione and androstenedione to testosterone. The primary antioxidant found in licorice root, the flavonoid glabridin, may inactivate or inhibit the activities of some cytochrome P450 enzymes. In tumor cells, beta-hydroxy-DHP, another flavonoid, may induce Bcl-2 phosphorylation, apoptosis, and G2/M cell cycle arrest.
NCI-GLOSS Definition: A substance prepared from dried roots of the plant Glycyrrhiza glabra. It is used as a flavoring in medicines, drinks, and sweets, and it is being studied in the treatment of cancer. Licorice root extract contains several compounds that reduce inflammation, kill certain bacteria and viruses, act like estrogen and other hormones, and may cause cancer cells to die. It is a type of antioxidant.
NCI Metathesaurus Link: C0086555 (see NCI Metathesaurus info)
Synonyms & Abbreviations: (see Synonym Details)
|Licorice Root Extract|
|licorice root extract|
External Source Codes:
|FDA UNII Code||61ZBX54883|
|PDQ Closed Trial Search ID||471833|
|PDQ Open Trial Search ID||471833 (check for NCI PDQ open clinical trial info)|
|Name||Value (qualifiers indented underneath)|
Additional Concept Data:
|Defined Fully by Roles: No|