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Version: 17.06d (Release date: 2017-06-26)
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Licorice (Code C61436)

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Terms & Properties

Preferred Name: Licorice

Definition: An herbal extract derived from the root of the plant Glycyrrhiza glabra with potential anti-inflammatory, antioxidant, and antineoplastic activities. Licorice root extract contains glycoside glycyrrhizinic acid and numerous flavonoids. Glycyrrhizinic acid in licorice root extract is hydrolyzed to glycyrrhetic acid (GA); GA inhibits 11 beta-hydroxysteroid dehydrogenase, resulting in inhibition of the conversion of cortisol to the inactive steroid cortisone and elevated cortisol levels. In addition, GA inhibits 17,20-lyase and 17 beta-hydroxysteroid dehydrogenase, resulting in decreased conversions of 17-hydroxyprogesterone to androstenedione and androstenedione to testosterone. The primary antioxidant found in licorice root, the flavonoid glabridin, may inactivate or inhibit the activities of some cytochrome P450 enzymes. In tumor cells, beta-hydroxy-DHP, another flavonoid, may induce Bcl-2 phosphorylation, apoptosis, and G2/M cell cycle arrest.

NCI-GLOSS Definition: A substance prepared from dried roots of the plant Glycyrrhiza glabra. It is used as a flavoring in medicines, drinks, and sweets, and it is being studied in the treatment of cancer. Licorice root extract contains several compounds that reduce inflammation, kill certain bacteria and viruses, act like estrogen and other hormones, and may cause cancer cells to die. It is a type of antioxidant.

Label: Licorice

NCI Thesaurus Code: C61436 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0086555  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Glycyrrhizae Radix
Licorice Root Extract
licorice root extract

External Source Codes: 
FDA UNII Code 61ZBX54883
PDQ Closed Trial Search ID 471833
PDQ Open Trial Search ID 471833 (check for NCI PDQ open clinical trial info)
UMLS CUI C0086555

Other Properties:
     Name Value (qualifiers indented underneath)
code C61436
Contributing_Source FDA
Legacy_Concept_Name Licorice_Root_Extract
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  


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