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National Cancer Institute
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Version: 17.08d (Release date: 2017-08-28)
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SR31747A (Code C61435)

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Terms & Properties

Preferred Name: SR31747A

Definition: A synthetic peripheral sigma receptor ligand with immunomodulatory and potential antitumor activities. Although the exact mechanism by which SR31747A exerts its antitumor effects has not been fully established, SR31747A binds to and inhibits the sigma1 receptor (SR31747A-binding protein-1 or SR-BP1), human sterol isomerase (emopamil-binding protein) and the sigma2 receptor, which may result in a reduction in tumor cell proliferation and tumor cell apoptosis. In addition, this agent inhibits the production of pro-inflammatory cytokines while increasing anti-inflammatory cytokines. Upregulated in various cancers, the sigma1 and sigma2 receptors and human sterol isomerase are proteins that are involved in the regulation of cell proliferation and survival.

Label: SR31747A

NCI Thesaurus Code: C61435 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C1831763  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)

External Source Codes: 
PDQ Closed Trial Search ID 471256
PDQ Open Trial Search ID 471256 (check for NCI PDQ open clinical trial info)
UMLS CUI C1831763

Other Properties:
     Name Value (qualifiers indented underneath)
code C61435
Legacy_Concept_Name SR31747A
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  


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