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Version: 17.06d (Release date: 2017-06-26)
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Lidocaine (Code C614)

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Terms & Properties

Preferred Name: Lidocaine

Definition: A synthetic aminoethylamide with local anesthetic and antiarrhythmic properties. Lidocaine stabilizes the neuronal membrane by binding to and inhibiting voltage-gated sodium channels, thereby inhibiting the ionic fluxes required for the initiation and conduction of impulses and effecting local anesthesia.

NCI-GLOSS Definition: A substance used to relieve pain by blocking signals at the nerve endings in skin. It can also be given intravenously to stop heart arrhythmias. It is a type of local anesthetic and antiarrhythmic.

Display Name: Lidocaine

Label: Lidocaine

NCI Thesaurus Code: C614 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0023660  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
.omega.-Diethylamino-2,6-dimethylacetanilide
2-(Diethylamino)-2',6'-acetoxylidide
2-(Diethylamino)-N-(2,6-dimethylphenyl)acetamide
2-Diethylamino-2',6'-acetoxylidide
Cuivasil
Duncaine
Leostesin
Lidocaine
LIDOCAINE
lidocaine
Lidothesin
Lignocaine
Omega-diethylamino-2,6-dimethylacetanilide
Rucaina

External Source Codes: 
CAS Registry Number 137-58-6 (see NLM ChemIDplus info)
FDA UNII Code 98PI200987
ChEBI ID CHEBI:6456 (see ChEBI info)
NSC Code 40030 (see NCI DTP info)
PDQ Closed Trial Search ID 39607
PDQ Open Trial Search ID 39607 (check for NCI PDQ open clinical trial info)
UMLS CUI C0023660

Other Properties:
     Name Value (qualifiers indented underneath)
Accepted_Therapeutic_Use_For Cardiac arrhythmias; Local anesthetic
Chemical_Formula C14H22N2O
code C614
Contributing_Source CTRP
Contributing_Source FDA
Legacy_Concept_Name Lidocaine
Semantic_Type Organic Chemical
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C614

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