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National Cancer Institute
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Version: 17.12d (Release date: 2017-12-26)
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Z-360 (Code C61329)

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Terms & Properties

Preferred Name: Z-360

Definition: A selective, orally available, 1,5-benzodiazepine-derivative gastrin/cholecystokinin 2 (CCK-2) receptor antagonist with potential antineoplastic activity. Z-360 binds to the gastrin/CCK-2 receptor, thereby preventing receptor activation by gastrin, a peptide hormone frequently associated with the proliferation of gastrointestinal and pancreatic tumor cells.

Label: Z-360

NCI Thesaurus Code: C61329 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C1831827  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)

External Source Codes: 
PDQ Closed Trial Search ID 485295
PDQ Open Trial Search ID 485295 (check for NCI PDQ open clinical trial info)
PubMedID Primary Reference 17961733 (see PubMed Primary Reference info)
UMLS CUI C1831827

Other Properties:
     Name Value (qualifiers indented underneath)
code C61329
Legacy_Concept_Name Z-360
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  


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