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Version: 17.06d (Release date: 2017-06-26)
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Xaliproden Hydrochloride (Code C61328)

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Terms & Properties

Preferred Name: Xaliproden Hydrochloride

Definition: The hydrochloride salt of xaliproden, an orally-active, synthetic, non-peptidic 5-hydroxytryptamine (5-HT) 1A receptor agonist with neurotrophic and neuroprotective activities. Although its mechanism of action is not fully understood, xaliproden appears to either mimic the effects of neurotrophins or stimulate their synthesis, thereby stimulating neuronal cell differentiation and proliferation and inhibiting neuronal cell death. The neuroprotective effect of this agent involves the activation of MAP kinase pathways via stimulation of the 5-HT1A receptor.

Display Name: Xaliproden Hydrochloride

Label: Xaliproden Hydrochloride

NCI Thesaurus Code: C61328 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0247952  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
1,2,3,6-tetrahydro-1-[2-(2-naphthalenyl)ethyl]-4-(3-(trifluoromethyl)phenyl)pyridine Hydrochloride
SR-57746A
Xaliproden Hydrochloride
XALIPRODEN HYDROCHLORIDE

External Source Codes: 
CAS Registry Number 90494-79-4 (see NLM ChemIDplus info)
FDA UNII Code 44D5EE8E26
PDQ Closed Trial Search ID 480399
PDQ Open Trial Search ID 480399 (check for NCI PDQ open clinical trial info)
UMLS CUI C0247952

Other Properties:
     Name Value (qualifiers indented underneath)
Chemical_Formula C24H22F3N.ClH
code C61328
Contributing_Source CTRP
Contributing_Source FDA
Legacy_Concept_Name Xaliproden_Hydrochloride
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C61328

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