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Version: 17.12d (Release date: 2017-12-26)
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Ezatiostat Hydrochloride (Code C61326)

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Terms & Properties

Preferred Name: Ezatiostat Hydrochloride

Definition: A liposomal small-molecule glutathione analog inhibitor of glutathione S-transferase (GST) P1-1 with hematopoiesis-stimulating activity. After intracellular de-esterification, the active form of TLK199 (TLK117) binds to and inhibits GST P1-1, thereby restoring Jun kinase and MAPK pathway activities and promoting MAPK-mediated cellular proliferation and differentiation pathways. This agent promotes the proliferation and maturation of hematopoietic precursor cells, granulocytes, monocytes, erythrocytes and platelets.

Display Name: Ezatiostat Hydrochloride

Label: Ezatiostat Hydrochloride

NCI Thesaurus Code: C61326 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C1613942  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Ezatiostat Hydrochloride

External Source Codes: 
CAS Registry Number 286942-97-0 (see NLM ChemIDplus info)
FDA UNII Code D59N834676
PDQ Closed Trial Search ID 485244
PDQ Open Trial Search ID 485244 (check for NCI PDQ open clinical trial info)
UMLS CUI C1613942

Other Properties:
     Name Value (qualifiers indented underneath)
Chemical_Formula C27H35N3O6S.HCl
code C61326
Contributing_Source CTRP
Contributing_Source FDA
Legacy_Concept_Name TLK199
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  


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