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National Cancer Institute
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Version: 17.06d (Release date: 2017-06-26)
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Oligonucleotide SPC2996 (Code C61325)

Terms & Properties Synonym Details Relationships Mapping View All  
Terms & Properties

Preferred Name: Oligonucleotide SPC2996

Definition: A synthetic antisense oligonucleotide against Bcl-2 messenger RNA with potential antitumor activity. Oligonucleotide SPC2996 binds to and inactivates Bcl-2 mRNA, thereby inhibiting the expression of Bcl-2 protein, promoting tumor cell apoptosis, and potentially enhancing the efficacy of standard cytotoxic chemotherapy. Linked to tumor drug resistance, the antiapoptotic protein Bcl-2 is upregulated in several types of cancers.

Label: Oligonucleotide SPC2996

NCI Thesaurus Code: C61325 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C1831825  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Oligonucleotide SPC2996

External Source Codes: 
PDQ Closed Trial Search ID 485272
PDQ Open Trial Search ID 485272 (check for NCI PDQ open clinical trial info)
UMLS CUI C1831825

Other Properties:
     Name Value (qualifiers indented underneath)
code C61325
Legacy_Concept_Name SPC2996_Oligonucleotide
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C61325

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