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National Cancer Institute
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Version: 17.12d (Release date: 2017-12-26)
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Senna Extract (Code C61324)

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Terms & Properties

Preferred Name: Senna Extract

Definition: An extract made from the dried leaflets on the pods of Cassia angustifolia or Cassia acutifolia with cathartic activity. Dimeric glycosides in dried senna extract are converted to the active monoanthrones by bacterial action in the colon. Through direct effects on enterocytes, enteric neurons, and muscle, monoanthrones produce giant migrating colonic contractions in addition to water and electrolyte secretion. As do other stimulant laxatives, monoanthrones may induce a limited low-grade inflammation in the colon through activation of prostaglandin/cyclic AMP and nitric oxide/cyclic GMP pathways and perhaps inhibition of Na+, K+-ATPase.

Label: Senna Extract

NCI Thesaurus Code: C61324 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0036656  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Senna Extract

External Source Codes: 
PDQ Closed Trial Search ID 480408
PDQ Open Trial Search ID 480408 (check for NCI PDQ open clinical trial info)
UMLS CUI C0036656

Other Properties:
     Name Value (qualifiers indented underneath)
code C61324
Legacy_Concept_Name Senna_Extract
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  


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