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Version: 17.12d (Release date: 2017-12-26)
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Recombinant Thyrotropin Alfa (Code C61322)

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Terms & Properties

Preferred Name: Recombinant Thyrotropin Alfa

Definition: A recombinant form of the human anterior pituitary glycoprotein thyroid stimulating hormone (TSH) with use in the diagnostic setting. With an amino acid sequence identical to that of human TSH, thyrotropin alfa binds to TSH receptors on normal thyroid epithelial cells or well-differentiated thyroid cancer cells, stimulating iodine uptake and organification, synthesis and secretion of thyroglobulin (Tg), triiodothyronine (T3), and thyroxine (T4).

NCI-GLOSS Definition: A form of thyroid-stimulating hormone (TSH) that is made in the laboratory. It is used to test for remaining or recurring cancer cells in patients who have been treated for thyroid cancer.

Display Name: Recombinant Thyrotropin Alfa

Label: Recombinant Thyrotropin Alfa

NCI Thesaurus Code: C61322 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0876183  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Recombinant Thyrotropin Alfa
Recombinant Thyrotropin Alpha
Recombinant TSH Alpha
Thyroid Stimulating Hormone Alpha
Thyrotropin Alfa
thyrotropin alfa

External Source Codes: 
CAS Registry Number 194100-83-9 (see NLM ChemIDplus info)
PDQ Closed Trial Search ID 481277
PDQ Open Trial Search ID 481277 (check for NCI PDQ open clinical trial info)
UMLS CUI C0876183

Other Properties:
     Name Value (qualifiers indented underneath)
code C61322
Contributing_Source CTRP
Contributing_Source FDA
Legacy_Concept_Name Recombinant_Thyrotropin_Alfa
Semantic_Type Amino Acid, Peptide, or Protein
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  


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