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Version: 17.06d (Release date: 2017-06-26)
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Methazolamide (Code C61318)

Terms & Properties Synonym Details Relationships Mapping View All  
Terms & Properties

Preferred Name: Methazolamide

Definition: A sulfonamide derivate and carbonic anhydrase inhibitor with potential antineoplastic activity. Methazolamide inhibits tumor-associated carbonic anhydrase IX (CAIX), which may result in increased cell death in hypoxic tumors. As a hypoxia-inducible transmembrane glycoprotein, CAIX catalyzes the rapid interconversion of carbon dioxide and water into carbonic acid, protons, and bicarbonate ions, helping to maintain acidification of the tumor microenvironment and enhance resistance to cytotoxic therapy in some hypoxic tumors.

Label: Methazolamide

NCI Thesaurus Code: C61318 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0025631  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Glauctabs
Methazolamide
METHAZOLAMIDE
MZM
N-[5-(aminosulfonyl)-3-methyl-1,3,4-thiadiazol-2(3H)-ylidene]-acetamide
Neptazane

External Source Codes: 
CAS Registry Number 554-57-4 (see NLM ChemIDplus info)
FDA UNII Code W733B0S9SD
PDQ Closed Trial Search ID 484587
PDQ Open Trial Search ID 484587 (check for NCI PDQ open clinical trial info)
UMLS CUI C0025631

Other Properties:
     Name Value (qualifiers indented underneath)
Chemical_Formula C5H8N4O3S2
code C61318
Contributing_Source FDA
Legacy_Concept_Name Methazolamide
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C61318

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