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National Cancer Institute
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Version: 17.06d (Release date: 2017-06-26)
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Liposome-Encapsulated Doxorubicin Citrate (Code C61317)

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Terms & Properties

Preferred Name: Liposome-Encapsulated Doxorubicin Citrate

Definition: A formulation of the citrate salt of the antineoplastic anthracycline antibiotic doxorubicin, encapsulated within liposomes, with antitumor activity. Doxorubicin intercalates into DNA and interacts with topoisomerase II, thereby inhibiting DNA replication and RNA synthesis. This agent also interacts with cell membrane lipids causing lipid peroxidation. Liposomal delivery of doxorubicin improves drug penetration into tumors and decreases drug clearance, thereby increasing the duration of therapeutic drug effects while lowering the toxicity profile.

NCI-GLOSS Definition: A form of the anticancer drug doxorubicin citrate that is contained inside very tiny, fat-like particles. It is being studied in the treatment of breast cancer that has spread and in the treatment of other types of cancer. Doxorubicin citrate damages DNA and may kill cancer cells. Liposomal-encapsulated doxorubicin citrate may have fewer side effects and may work better than doxorubicin citrate.

Display Name: Liposome-Encapsulated Doxorubicin Citrate

Label: Liposome-Encapsulated Doxorubicin Citrate

NCI Thesaurus Code: C61317 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C1512062  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Liposome-Encapsulated Doxorubicin Citrate
liposome-encapsulated doxorubicin citrate

External Source Codes: 
PDQ Closed Trial Search ID 481301
PDQ Open Trial Search ID 481301 (check for NCI PDQ open clinical trial info)
UMLS CUI C1512062

Other Properties:
     Name Value (qualifiers indented underneath)
code C61317
Contributing_Source CTRP
Legacy_Concept_Name Liposome-Encapsulated_Doxorubicin_Citrate
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  


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