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National Cancer Institute
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Version: 17.06d (Release date: 2017-06-26)
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INO-1001 (Code C61315)

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Terms & Properties

Preferred Name: INO-1001

Definition: A isoindolinone derivative and potent inhibitor of the nuclear enzyme poly (ADP-ribose) polymerase (PARP) with chemosensitization and radiosensitization properties. INO-1001 inhibits PARP, which may result in inhibition of tumor cell DNA repair mechanisms and, so, tumor cell resistance to chemotherapy and radiation therapy. PARP enzymes are activated by DNA breaks and have been implicated in the repair of DNA single-strand breaks (SSB).

Label: INO-1001

NCI Thesaurus Code: C61315 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C1504945  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
INO 1001

External Source Codes: 
CAS Registry Number 624747-02-0 (see NLM ChemIDplus info)
PDQ Closed Trial Search ID 485165
PDQ Open Trial Search ID 485165 (check for NCI PDQ open clinical trial info)
UMLS CUI C1504945

Other Properties:
     Name Value (qualifiers indented underneath)
code C61315
Legacy_Concept_Name INO-1001
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  


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