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Version: 16.10e (Release date: 2016-10-31)
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Denosumab (Code C61313)

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Terms & Properties

Preferred Name: Denosumab

Definition: A fully human monoclonal antibody directed against the receptor activator of nuclear factor kappa beta ligand (RANKL) with antiosteoclast activity. Denosumab specifically binds to RANKL and blocks the interaction of RANKL with RANK, a receptor located on osteoclast cell surfaces, resulting in inhibition of osteoclast activity, a decrease in bone resorption, and a potential increase in bone mineral density. RANKL, a protein expressed by osteoblastic cells, plays an important role in osteoclastic differentiation and activation.

NCI-GLOSS Definition: A type of monoclonal antibody being studied in the treatment of multiple myeloma (a cancer that forms in bones) and in the prevention and treatment of bone metastases (cancer that has spread to bone from another organ). Monoclonal antibodies are made in the laboratory and can locate and bind to substances in the body, including cancer cells. AMG 162 binds to the protein RANKL and helps keep bone from breaking down.

Display Name: Denosumab

Label: Denosumab

NCI Thesaurus Code: C61313 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C1690432  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
AMG-162
AMG 162
Denosumab
DENOSUMAB
denosumab
Prolia
Xgeva

External Source Codes: 
CAS Registry Number 615258-40-7 (see NLM ChemIDplus info)
FDA UNII Code 4EQZ6YO2HI
PDQ Closed Trial Search ID 481348
PDQ Open Trial Search ID 481348 (check for NCI PDQ open clinical trial info)
UMLS CUI C1690432

Other Properties:
Name Value (qualifiers indented underneath)
Accepted_Therapeutic_Use_For Osteolytic Bone Metastases of Solid Tumors
code C61313
Contributing_Source CTRP
Contributing_Source FDA
Legacy_Concept_Name Densosumab
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C61313

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