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Version: 17.06d (Release date: 2017-06-26)
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Folitixorin (Code C61304)

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Terms & Properties

Preferred Name: Folitixorin

Definition: A folate-based biomodulator with potential antineoplastic activity. 5,10-methylenetetrahydrofolate (MTHF) stabilizes the covalent binding of the fluorouracil metabolite 5-5-fluoro-2'-deoxyuridine-5'-O-monophosphate (FdUMP) to its target enzyme, thymidylate synthase, which results in inhibition of thymidylate synthase, depletion of thymidine triphosphate (TTP), a necessary constituent of DNA, and tumor cell death. Unlike leucovorin, MTHF, as the active form of folate, does not require metabolic activation and may increase the chemotherapeutic effects of fluorouracil with lower toxicity.

Label: Folitixorin

NCI Thesaurus Code: C61304 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0048858  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
5,10-methylene-5,6,7,8-tetrahydrofolic Acid
N-(4-(3-Amino-1,2,5,6,6a,7-hexahydro-1-oxoimidazo(1,5-f)pteridin-8(9H)-yl)benzoyl)-L-glutamic Acid

External Source Codes: 
CAS Registry Number 3432-99-3 (see NLM ChemIDplus info)
ChEBI ID CHEBI:1989 (see ChEBI info)
PDQ Closed Trial Search ID 405875
PDQ Open Trial Search ID 405875 (check for NCI PDQ open clinical trial info)
UMLS CUI C0048858

Other Properties:
     Name Value (qualifiers indented underneath)
Chemical_Formula C20H23N7O6
code C61304
Contributing_Source FDA
Legacy_Concept_Name _5_10-Methylenetetrahydrofolate
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  


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