|TLR7 Agonist 852A (Code C61104)|
|Terms & Properties|
Preferred Name: TLR7 Agonist 852A
Definition: A synthetic imidazoquinoline Toll-like receptor 7 (TLR7) agonist with immunostimulating and potential antitumor activities. TLR7 agonist 852A binds to and activates TLR7, thereby stimulating plasmacytoid dendritic cells (pDC) through the TLR7-MyD88-dependent signaling pathway. Activation of pDC results in secretion of interferon alpha, the production of proimflammatory cytokines, the upregulation of co-stimulatory molecules, and enhanced T and B-cell stimulatory responses.
NCI-GLOSS Definition: A substance being studied in the treatment of certain adult and childhood blood cancers and other types of cancer. 852A may help the patient's immune system block tumor growth. It is a type of immune system modulator.
Label: TLR7 Agonist 852A
NCI Metathesaurus Link: C1541384 (see NCI Metathesaurus info)
Synonyms & Abbreviations: (see Synonym Details)
|TLR7 Agonist 852A|
External Source Codes:
|PDQ Closed Trial Search ID||396824|
|PDQ Open Trial Search ID||396824 (check for NCI PDQ open clinical trial info)|
|Name||Value (qualifiers indented underneath)|
Additional Concept Data:
|Defined Fully by Roles: No|