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Version: 17.06d (Release date: 2017-06-26)
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TLR7 Agonist 852A (Code C61104)

Terms & Properties Synonym Details Relationships Mapping View All  
Terms & Properties

Preferred Name: TLR7 Agonist 852A

Definition: A synthetic imidazoquinoline Toll-like receptor 7 (TLR7) agonist with immunostimulating and potential antitumor activities. TLR7 agonist 852A binds to and activates TLR7, thereby stimulating plasmacytoid dendritic cells (pDC) through the TLR7-MyD88-dependent signaling pathway. Activation of pDC results in secretion of interferon alpha, the production of proimflammatory cytokines, the upregulation of co-stimulatory molecules, and enhanced T and B-cell stimulatory responses.

NCI-GLOSS Definition: A substance being studied in the treatment of certain adult and childhood blood cancers and other types of cancer. 852A may help the patient's immune system block tumor growth. It is a type of immune system modulator.

Label: TLR7 Agonist 852A

NCI Thesaurus Code: C61104 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C1541384  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
852A
TLR7 Agonist 852A

External Source Codes: 
PDQ Closed Trial Search ID 396824
PDQ Open Trial Search ID 396824 (check for NCI PDQ open clinical trial info)
UMLS CUI C1541384

Other Properties:
     Name Value (qualifiers indented underneath)
code C61104
Legacy_Concept_Name _852A
Semantic_Type Organic Chemical
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C61104

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