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Version: 16.10e (Release date: 2016-10-31)
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Noscapine Hydrochloride (Code C61103)

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Terms & Properties

Preferred Name: Noscapine Hydrochloride

Definition: The orally available hydrochloride salt of the opioid agonist noscapine, a phthalideisoquinoline alkaloid derived from the opium poppy Papaver somniferum, with mild analgesic, antitussive, and potential antineoplastic activities. Noscapine binds to tubulin and alters its conformation, resulting in a disruption of the dynamics of microtubule assembly (by increasing the time that microtubules spend idle in a paused state) and subsequently, the inhibition of mitosis and tumor cell death. Unlike other tubulin inhibitors such as the taxanes and vinca alkaloids, noscapine does not affect microtubule polymerization.

Display Name: Noscapine Hydrochloride

Label: Noscapine Hydrochloride

NCI Thesaurus Code: C61103 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C1450474  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
1(3H)Isobenzofuranone,6,7-dimethoxy-3-(5,6,7,8-tetrahydro-4-methoxy-6-methyl-1,3,-dioxolo(4,5-g)isoquinolin-5-yl)-hydrochloride
Narcotine hydrochloride
Noscapine HCl
Noscapine Hydrochloride
NOSCAPINE HYDROCHLORIDE

External Source Codes: 
CAS Registry Number 912-60-7 (see NLM ChemIDplus info)
FDA UNII Code TTN62ITH9I
PDQ Closed Trial Search ID 469778
PDQ Open Trial Search ID 469778 (check for NCI PDQ open clinical trial info)
UMLS CUI C1450474

Other Properties:
Name Value (qualifiers indented underneath)
Accepted_Therapeutic_Use_For Cough
Chemical_Formula C22H23NO7.HCl
code C61103
Contributing_Source CTRP
Contributing_Source FDA
Legacy_Concept_Name Noscapine_Hydrochloride
Semantic_Type Organic Chemical
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C61103

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