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Version: 17.06d (Release date: 2017-06-26)
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Levodopa (Code C611)

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Terms & Properties

Preferred Name: Levodopa

Definition: An amino acid precursor of dopamine with antiparkinsonian properties. Levodopa is a prodrug that is converted to dopamine by DOPA decarboxylase and can cross the blood-brain barrier. When in the brain, levodopa is decarboxylated to dopamine and stimulates the dopaminergic receptors, thereby compensating for the depleted supply of endogenous dopamine seen in Parkinson's disease. To assure that adequate concentrations of levodopa reach the central nervous system, it is administered with carbidopa, a decarboxylase inhibitor that does not cross the blood-brain barrier, thereby diminishing the decarboxylation and inactivation of levodopa in peripheral tissues and increasing the delivery of dopamine to the CNS.

Label: Levodopa

NCI Thesaurus Code: C611 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0023570  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
(-)-3-(3,4-Dihydroxyphenyl)-L-alanine
(--)-2Amino-3-(3,4-dihydroxyphenyl)propanoic Acid
(--)-3-(3,4-Dihydroxyphenyl)-L-alanine
.beta.-(3,4-Dihydroxyphenyl)-L-alanine
3-(3,4-Dihydroxyphenyl)-L-alanine
3-Hydroxy-L-tyrosine
Bendopa
beta-(3,4-Dihydroxyphenyl)-L-alanine
Cidandopa
Deadopa
Dopaflex
Dopaidan
Dopal
Dopalina
Dopar
Doparkine
Doparl
Dopasol
Dopaston
Dopastral
Doprin
Eldopal
Eldopar
Eldopatec
Eurodopa
L(-)-Dopa
L-.beta.-(3,4-Dihydroxyphenyl)alanine
L-Dopa
L-DOPA
Laradopa
Larodopa
Ledopa
LEVODOPA
Levodopa
Levopa
Maipedopa
Parda
Veldopa

External Source Codes: 
CAS Registry Number 59-92-7 (see NLM ChemIDplus info)
FDA UNII Code 46627O600J
ChEBI ID CHEBI:15765 (see ChEBI info)
NSC Code 118381 (see NCI DTP info)
PDQ Closed Trial Search ID 42622
PDQ Open Trial Search ID 42622 (check for NCI PDQ open clinical trial info)
UMLS CUI C0023570

Other Properties:
     Name Value (qualifiers indented underneath)
Chemical_Formula C9H11NO4
code C611
Contributing_Source FDA
Legacy_Concept_Name Levodopa
Semantic_Type Amino Acid, Peptide, or Protein
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C611

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