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Version: 17.06d (Release date: 2017-06-26)
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Nedaplatin (Code C61099)

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Terms & Properties

Preferred Name: Nedaplatin

Definition: A second-generation cisplatin analogue with antineoplastic activity. Containing a novel ring structure in which glycolate is bound to the platinum by a bidentate ligand, nedaplatin forms reactive platinum complexes that bind to nucelophillic groups in DNA, resulting in intrastrand and interstrand DNA cross-links, apoptosis and cell death. This agent appears to be less nephrotoxic and neurotoxic compared to both cisplatin and carboplatin.

Label: Nedaplatin

NCI Thesaurus Code: C61099 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0093999  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
(Glycolato-O,O')diammineplatinum(II)
254-S
CDGP
cis-Diammine(glucolato)platinum
NDP
Nedaplatin
NEDAPLATIN

External Source Codes: 
CAS Registry Number 95734-82-0 (see NLM ChemIDplus info)
FDA UNII Code 8UQ3W6JXAN
ChEBI ID CHEBI:31898 (see ChEBI info)
PDQ Closed Trial Search ID 468844
PDQ Open Trial Search ID 468844 (check for NCI PDQ open clinical trial info)
UMLS CUI C0093999

Other Properties:
     Name Value (qualifiers indented underneath)
Chemical_Formula C2H2O3.Pt.2H3N
code C61099
Contributing_Source FDA
Legacy_Concept_Name Nedaplatin
Semantic_Type Inorganic Chemical
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C61099

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