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Version: 17.06d (Release date: 2017-06-26)
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Adenovirus HER2-Transduced Autologous Dendritic Cell Vaccine (Code C61098)

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Terms & Properties

Preferred Name: Adenovirus HER2-Transduced Autologous Dendritic Cell Vaccine

Definition: A cell-based cancer vaccine composed of autologous dendritic cells (DCs) transduced with a replication-deficient adenovirus vector encoding HER-2 with potential antineoplastic activity. Upon administration, adenovirus HER2-transduced autologous dendritic cell vaccine may stimulate a cytotoxic T lymphocyte (CTL) response against HER-2-positive tumor cells, which may result in tumor cell death and decreased tumor growth. HER-2, a tyrosine kinase receptor for epidermal growth factor (EGF) (also known as neu and ErbB2), is overexpressed by some breast, ovarian, and gastric cancers.

Display Name: Adenovirus HER2-Transduced Autologous Dendritic Cell Vaccine

Label: Adenovirus HER2-Transduced Autologous Dendritic Cell Vaccine

NCI Thesaurus Code: C61098 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C1831756  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Adenovirus HER2-Transduced Autologous Dendritic Cell Vaccine
AdHer2/DC
Autologous Dendritic Cell-Adenovirus HER2 Vaccine
autologous dendritic cell/adenovirus HER-2 vaccine
HER-2 pulsed DC vaccine

External Source Codes: 
PDQ Closed Trial Search ID 468842
PDQ Open Trial Search ID 468842 (check for NCI PDQ open clinical trial info)
UMLS CUI C1831756

Other Properties:
     Name Value (qualifiers indented underneath)
code C61098
Contributing_Source CTRP
Legacy_Concept_Name Adenovirus-transduced_HER-2_Autologous_Dendritic_Cell_Vaccine
Semantic_Type Immunologic Factor
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C61098

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