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Version: 17.06d (Release date: 2017-06-26)
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Ecromeximab (Code C61095)

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Terms & Properties

Preferred Name: Ecromeximab

Definition: A low-fucose, human-mouse chimeric IgG1 monoclonal antibody with potential antineoplastic activity targeting at the ganglioside GD3, a surface antigen expressed on many malignant melanoma cells. Monoclonal antibody KW-2871 binds to GD3-positive cells, thereby initiating antibody-dependent cytotoxicity against GD3-positive cells. This agent is prepared by fusing murine immunoglobulin (Ig) light and heavy variable regions derived from the murine IgG3 antibody KM-641 to a human constant (Fc) region. The low fucose content of the oligosaccharide side chains of this antibody may enhance binding of the antibody Fc region to lymphocyte Fc receptors.

Display Name: Ecromeximab

Label: Ecromeximab

NCI Thesaurus Code: C61095 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C1669509  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Chimeric Monoclonal Antibody KW-2871
Ecromeximab
ECROMEXIMAB
Immunoglobulin G1, Anti-(Gd3 Ganglioside) (Human-Mouse Monoclonal Km871 Gamma-1-Chain), Disulfide with Human-Mouse Monoclonal KM871 Kappa-Chain, Dimer
KM871
KW-2871
Monoclonal Antibody KW-2871

External Source Codes: 
CAS Registry Number 292819-64-8 (see NLM ChemIDplus info)
FDA UNII Code M76FX2JZRM
PDQ Closed Trial Search ID 467926
PDQ Open Trial Search ID 467926 (check for NCI PDQ open clinical trial info)
UMLS CUI C1669509

Other Properties:
     Name Value (qualifiers indented underneath)
code C61095
Contributing_Source CTRP
Contributing_Source FDA
Legacy_Concept_Name Monoclonal_Antibody_KW-2871
Semantic_Type Amino Acid, Peptide, or Protein
Semantic_Type Immunologic Factor
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C61095

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