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Version: 17.12d (Release date: 2017-12-26)
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Ecromeximab (Code C61095)

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Terms & Properties

Preferred Name: Ecromeximab

Definition: A low-fucose, human-mouse chimeric IgG1 monoclonal antibody with potential antineoplastic activity targeting at the ganglioside GD3, a surface antigen expressed on many malignant melanoma cells. Monoclonal antibody KW-2871 binds to GD3-positive cells, thereby initiating antibody-dependent cytotoxicity against GD3-positive cells. This agent is prepared by fusing murine immunoglobulin (Ig) light and heavy variable regions derived from the murine IgG3 antibody KM-641 to a human constant (Fc) region. The low fucose content of the oligosaccharide side chains of this antibody may enhance binding of the antibody Fc region to lymphocyte Fc receptors.

Display Name: Ecromeximab

Label: Ecromeximab

NCI Thesaurus Code: C61095 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C1669509  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Chimeric Monoclonal Antibody KW-2871
Immunoglobulin G1, Anti-(Gd3 Ganglioside) (Human-Mouse Monoclonal Km871 Gamma-1-Chain), Disulfide with Human-Mouse Monoclonal KM871 Kappa-Chain, Dimer
Monoclonal Antibody KW-2871

External Source Codes: 
CAS Registry Number 292819-64-8 (see NLM ChemIDplus info)
PDQ Closed Trial Search ID 467926
PDQ Open Trial Search ID 467926 (check for NCI PDQ open clinical trial info)
UMLS CUI C1669509

Other Properties:
     Name Value (qualifiers indented underneath)
code C61095
Contributing_Source CTRP
Contributing_Source FDA
Legacy_Concept_Name Monoclonal_Antibody_KW-2871
Semantic_Type Amino Acid, Peptide, or Protein
Semantic_Type Immunologic Factor
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  


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