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Version: 17.06d (Release date: 2017-06-26)
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Sepantronium Bromide (Code C61091)

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Terms & Properties

Preferred Name: Sepantronium Bromide

Definition: A small-molecule proapoptotic agent with potential antineoplastic activity. Sepantronium bromide selectively inhibits survivin expression in tumor cells, resulting in inhibition of survivin antiapoptotic activity (via the extrinsic or intrinsic apoptotic pathways) and tumor cell apoptosis. Survivin, a member of the inhibitor of apoptosis (IAP) gene family, is expressed during embryonal development and is absent in most normal, terminally differentiated tissues; upregulated in a variety of human cancers, its expression in tumors is associated with a more aggressive phenotype, shorter survival times, and a decreased response to chemotherapy.

Display Name: Sepantronium Bromide

Label: Sepantronium Bromide

NCI Thesaurus Code: C61091 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C2002939  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
1H-Naphth(2,3-d)imidazolium, 4,9-dihydro-1-(2-methoxyethyl)-2-methyl-4,9-dioxo-3-(pyrazinylmethyl)-, Bromide
Sepantronium Bromide
Survivin Inhibitor YM155

External Source Codes: 
CAS Registry Number 781661-94-7 (see NLM ChemIDplus info)
PDQ Closed Trial Search ID 476771
PDQ Open Trial Search ID 476771 (check for NCI PDQ open clinical trial info)
UMLS CUI C2002939

Other Properties:
     Name Value (qualifiers indented underneath)
Chemical_Formula C20H19N4O3.Br
code C61091
Contributing_Source CTRP
Contributing_Source FDA
Legacy_Concept_Name YM155
Semantic_Type Chemical Viewed Functionally

Additional Concept Data: 
Defined Fully by Roles: No  


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