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Version: 16.11d (Release date: 2016-11-28)
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Quadrivalent Human Papillomavirus (types 6, 11, 16, 18) Recombinant Vaccine (Code C61087)

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Terms & Properties

Preferred Name: Quadrivalent Human Papillomavirus (types 6, 11, 16, 18) Recombinant Vaccine

Definition: A non-infectious recombinant, quadrivalent vaccine prepared from the highly purified virus-like particles (VLPs) of the major capsid (L1) protein of human papillomavirus (HPV) types 6, 11, 16, and 18 with immunoprophylactic activity. L1 proteins are produced by separate fermentations in recombinant Saccharomyces cerevisiae, self-assembled into VLPs, and adsorbed onto amorphous aluminium hydroxyphosphate sulfate adjuvant following purification. The immunoprophylactic efficacy of L1 VLP vaccines, such as quadrivalent human papillomavirus (types 6,11,16,18) recombinant vaccine, appear to be mediated by the development of humoral immune responses. HPV Types 16 and 18 account for approximately 70% of cervical cancers and HPV Types 6 and 11 account for approximately 90% of genital warts.

NCI-GLOSS Definition: A vaccine used to prevent cervical, vulvar, and vaginal cancer caused by human papillomavirus (HPV) types 16 and 18 and genital warts caused by HPV types 6 and 11. It is also used to prevent lesions that are caused by these viruses and that can lead to cervical, vulvar, or vaginal cancer. Quadrivalent human papillomavirus (types 6, 11, 16, and 18) recombinant vaccine is used in females aged 9-26 years. It is also used to prevent genital warts in males aged 9-26 years. Quadrivalent human papillomavirus (types 6, 11, 16, and 18) recombinant vaccine is being studied in the treatment of other medical conditions.

Display Name: Quadrivalent Human Papillomavirus (types 6, 11, 16, 18) Recombinant Vaccine

Label: Quadrivalent Human Papillomavirus (types 6, 11, 16, 18) Recombinant Vaccine

NCI Thesaurus Code: C61087 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C1831799  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Gardasil
Quadrivalent HPV [Type 6, 11, 16 and 18] L1 Virus-Like Particle vaccine
Quadrivalent Human Papillomavirus (types 6, 11, 16, 18) Recombinant Vaccine
quadrivalent human papillomavirus (types 6, 11, 16, and 18) recombinant vaccine
Recombinant Human Papillomavirus (HPV) Quadrivalent Vaccine
V501

External Source Codes: 
PDQ Closed Trial Search ID 476576
PDQ Open Trial Search ID 476576 (check for NCI PDQ open clinical trial info)
UMLS CUI C1831799

Other Properties:
Name Value (qualifiers indented underneath)
code C61087
Contributing_Source CTRP
Legacy_Concept_Name Quadrivalent_Human_Papillomavirus_Recombinant_Vaccine
Semantic_Type Chemical Viewed Functionally

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C61087

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