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Version: 17.06d (Release date: 2017-06-26)
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Casopitant Mesylate (Code C61086)

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Terms & Properties

Preferred Name: Casopitant Mesylate

Definition: The mesylate salt of a centrally-acting neurokinin 1 (NK1) receptor antagonist with antidepressant and antiemetic activities. Casopitant competitively binds to and blocks the activity of the NK-receptor, thereby inhibiting NK1-receptor binding of the endogenous tachykinin neuropeptide substance P (SP), which may result in antiemetic effects. SP is found in neurons of vagal afferent fibers innervating the brain-stem nucleus tractus solitarii and the area postrema, which contains the chemoreceptor trigger zone (CTZ), and may be elevated in response to chemotherapy. The NK-receptor is a G-protein receptor coupled to the inositol phosphate signal-transduction pathway and is found in both the nucleus tractus solitarii and the area postrema.

Label: Casopitant Mesylate

NCI Thesaurus Code: C61086 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C1831797  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Casopitant Mesylate
CASOPITANT MESYLATE
GW679769

External Source Codes: 
CAS Registry Number 414910-30-8 (see NLM ChemIDplus info)
FDA UNII Code 7VSV9BL497
PDQ Closed Trial Search ID 476572
PDQ Open Trial Search ID 476572 (check for NCI PDQ open clinical trial info)
UMLS CUI C1831797

Other Properties:
     Name Value (qualifiers indented underneath)
Chemical_Formula C30H35F7N4O2.CH4O3S
code C61086
Contributing_Source FDA
Legacy_Concept_Name Casopitant
Semantic_Type Chemical Viewed Functionally

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C61086

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