skip navigation links
National Cancer Institute
EVS Logo NCI Term Browser Enterprise Vocabulary Services
Terminologies Value Sets Mappings
Version: 17.06d (Release date: 2017-06-26)
SearchBox Top
SearchBox Bottom
Casopitant Mesylate (Code C61086)

Terms & Properties Synonym Details Relationships Mapping View All  
Terms & Properties

Preferred Name: Casopitant Mesylate

Definition: The mesylate salt of a centrally-acting neurokinin 1 (NK1) receptor antagonist with antidepressant and antiemetic activities. Casopitant competitively binds to and blocks the activity of the NK-receptor, thereby inhibiting NK1-receptor binding of the endogenous tachykinin neuropeptide substance P (SP), which may result in antiemetic effects. SP is found in neurons of vagal afferent fibers innervating the brain-stem nucleus tractus solitarii and the area postrema, which contains the chemoreceptor trigger zone (CTZ), and may be elevated in response to chemotherapy. The NK-receptor is a G-protein receptor coupled to the inositol phosphate signal-transduction pathway and is found in both the nucleus tractus solitarii and the area postrema.

Label: Casopitant Mesylate

NCI Thesaurus Code: C61086 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C1831797  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Casopitant Mesylate

External Source Codes: 
CAS Registry Number 414910-30-8 (see NLM ChemIDplus info)
PDQ Closed Trial Search ID 476572
PDQ Open Trial Search ID 476572 (check for NCI PDQ open clinical trial info)
UMLS CUI C1831797

Other Properties:
     Name Value (qualifiers indented underneath)
Chemical_Formula C30H35F7N4O2.CH4O3S
code C61086
Contributing_Source FDA
Legacy_Concept_Name Casopitant
Semantic_Type Chemical Viewed Functionally

Additional Concept Data: 
Defined Fully by Roles: No  


Mainbox Bottom