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National Cancer Institute
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Version: 17.10e (Release date: 2017-10-30)
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Siltuximab (Code C61084)

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Terms & Properties

Preferred Name: Siltuximab

Definition: A chimeric, human-murine, monoclonal antibody targeting the pro-inflammatory cytokine interleukin 6 (IL-6), with antitumor and anti-inflammatory activities. Upon intravenous administration of siltuximab, this agent targets and binds to IL-6. This inhibits the binding of IL-6 to the IL-6 receptor (IL-6R), which results in the blockade of the IL-6/IL-6R-mediated signal transduction pathway. This inhibits cancer cell growth in tumors overexpressing IL-6.

NCI-GLOSS Definition: A chimeric (made from human and mouse proteins) monoclonal antibody being studied in the treatment of advanced kidney cancer and other types of cancer. Monoclonal antibodies are made in the laboratory and can locate and bind to substances in the body, including cancer cells. Anti-IL-6 chimeric monoclonal antibody works by blocking inflammation and tumor growth.

Display Name: Siltuximab

Label: Siltuximab

NCI Thesaurus Code: C61084 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C1609931  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
anti-IL-6 chimeric monoclonal antibody
Anti-IL-6 Chimeric Monoclonal Antibody
CNTO 328

External Source Codes: 
CAS Registry Number 541502-14-1 (see NLM ChemIDplus info)
PDQ Closed Trial Search ID 475765
PDQ Open Trial Search ID 475765 (check for NCI PDQ open clinical trial info)
UMLS CUI C1609931

Other Properties:
     Name Value (qualifiers indented underneath)
Accepted_Therapeutic_Use_For multicentric Castleman's disease (MCD)
code C61084
Contributing_Source CTRP
Contributing_Source FDA
Legacy_Concept_Name Anti-IL-6_Chimeric_Monoclonal_Antibody
Semantic_Type Amino Acid, Peptide, or Protein

Additional Concept Data: 
Defined Fully by Roles: No  


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