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Version: 17.06d (Release date: 2017-06-26)
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Sodium Stibogluconate (Code C61083)

Terms & Properties Synonym Details Relationships Mapping View All  
Terms & Properties

Preferred Name: Sodium Stibogluconate

Definition: Pentavalent antimony (Sb) in differential complex formation with gluconic acid with leishmanicidal and potential antineoplastic activities. The Sb moiety of sodium stibogluconate (SSG) may inhibit protein tyrosine phosphorylases (PTPases) by covalently modifying sulfhydryl groups in PTPase cysteine residues, resulting in specific inactivation of SH2 domain-containing tyrosine phosphatases-1 and -2 (SHP-1 and SHP-2), PTPases which negatively regulate interferon (IFN) signaling; enhancement of IFN-induced Stat1 tyrosine phosphorylation; and induction of cellular protein tyrosine phosphorylation. SSG in combination with IFN-alpha may synergize to overcome tumor cell resistance to IFN-alpha-mediated apoptosis.

NCI-GLOSS Definition: A substance being studied in the treatment of certain solid tumors, lymphoma, and myeloma. Sodium stibogluconate may block enzymes needed for cancer growth. It is a type of pentavalent antimonial.

Display Name: Sodium Stibogluconate

Label: Sodium Stibogluconate

NCI Thesaurus Code: C61083 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0030895  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Antimony Sodium Gluconate
Lenocta
Myostibin
Pentostam
Sodium Stibogluconate
SODIUM STIBOGLUCONATE
sodium stibogluconate
Solustibosan
Solustin
SSG
VQD001

External Source Codes: 
CAS Registry Number 12001-86-4 (see NLM ChemIDplus info)
CAS Registry Number 16037-91-5 (see NLM ChemIDplus info)
FDA UNII Code V083S0159D
ChEBI ID CHEBI:28148 (see ChEBI info)
PDQ Closed Trial Search ID 475763
PDQ Open Trial Search ID 475763 (check for NCI PDQ open clinical trial info)
UMLS CUI C0030895

Other Properties:
     Name Value (qualifiers indented underneath)
Chemical_Formula C12H18O17Sb2.2Na
code C61083
Contributing_Source CTRP
Contributing_Source FDA
Legacy_Concept_Name Sodium_Stibogluconate
Semantic_Type Chemical Viewed Functionally
Semantic_Type Organic Chemical
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C61083

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