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Version: 17.06d (Release date: 2017-06-26)
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Algenpantucel-L (Code C61082)

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Terms & Properties

Preferred Name: Algenpantucel-L

Definition: A cancer vaccine comprised of irradiated allogeneic pancreatic cancer cells transfected to express murine alpha-1,3-galactosyltransferase with potential antitumor activity. Vaccination is associated with the expression of murine alpha-1,3-galactosyl (alpha-gal) carbohydrate residues on cell membrane glycoproteins and glycolipids of the vaccine pancreatic cancer cell allograft; murine alpha-gal epitopes, not present on human cells, then induce a hyperacute rejection of the vaccine pancreatic cancer cell allograft. The hyperacute rejection involves the binding of pre-existing human anti-alpha-gal antibodies (which naturally occur against gut flora) to murine alpha-gal epitopes, resulting in the rapid activation of antibody-dependent cell-mediated cytotoxicity (ADCC) towards allograft cells. The host immune system then attacks endogenous pancreatic cancer cells, resulting in ADCC towards endogenous pancreatic cancer cells.

Display Name: Algenpantucel-L

Label: Algenpantucel-L

NCI Thesaurus Code: C61082 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C1831790  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Algenpantucel-L
Alpha-1,3-Galactosyltransferase-expressing Allogeneic Pancreatic Tumor Cell Vaccine
Alpha (1,3) Galactosyltransferase Tumor Vaccine
HAPa
HyperAcute-Pancreas Immunotherapy
Hyperacute Pancreatic Cancer Vaccine

External Source Codes: 
PDQ Closed Trial Search ID 475734
PDQ Open Trial Search ID 475734 (check for NCI PDQ open clinical trial info)
UMLS CUI C1831790

Other Properties:
     Name Value (qualifiers indented underneath)
code C61082
Contributing_Source CTRP
Legacy_Concept_Name Alpha-Gal_Pancreatic_Cancer_Vaccine
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C61082

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