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Version: 17.06d (Release date: 2017-06-26)
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ISS 1018 CpG Oligodeoxynucleotide (Code C61080)

Terms & Properties Synonym Details Relationships Mapping View All  
Terms & Properties

Preferred Name: ISS 1018 CpG Oligodeoxynucleotide

Definition: A short, synthetic, unmethylated CpG motif-based oligodeoxynucleotide (CpG ODN) with immunostimulatory activity. As an immunostimulatory sequence (ISS) that signals through Toll-like receptor 9 (TLR9), ISS 1018 CpG ODN induces the production of immunoglobulin by B cells and interferon (IFN) -alpha, IFN-beta, interleukin (IL) -12, and tumor necrosis factor (TNF) -alpha by plasmacytoid dendritic cells (pDC). pDC, through cell-cell contact, and IFN-alpha and -beta, in turn, induce natural killer (NK) cell proliferation, NK cell production of IFN-gamma, and NK cell-mediated cytotoxicity; secreted IFNs also stimulate bystander T cell activation and differentiation of naive CD4+ T cells into T-helper 1 cells on specific antigen challenge. In addition, ISS 1018 CpG ODN promotes antigen presentation and co-stimulatory molecule expression.

Label: ISS 1018 CpG Oligodeoxynucleotide

NCI Thesaurus Code: C61080 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C1831789  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
ISS 1018 CpG Oligodeoxynucleotide

External Source Codes: 
PDQ Closed Trial Search ID 474964
PDQ Open Trial Search ID 474964 (check for NCI PDQ open clinical trial info)
UMLS CUI C1831789

Other Properties:
     Name Value (qualifiers indented underneath)
code C61080
Legacy_Concept_Name ISS1018_Oligodeoxynucleotide
Semantic_Type Chemical Viewed Structurally

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C61080

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