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Version: 16.10e (Release date: 2016-10-31)
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Sagopilone (Code C61072)

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Terms & Properties

Preferred Name: Sagopilone

Definition: A fully synthetic low-molecular-weight epothilone with potential antineoplastic activity. Sagopilone binds to tubulin and induces microtubule polymerization while stabilizing microtubules against depolymerization, which may result in the inhibition of cell division, the induction of G2/M arrest, and apoptosis. The agent is not a substrate for the P-glycoprotein (P-gp) efflux pump and so may exhibit activity in multidrug-resistant (MDR) tumors. The epothilone class of metabolites was originally isolated from the myxobacterium Solangium cellulosum.

NCI-GLOSS Definition: A form of the substance epothilone that is made in the laboratory. It is being studied in the treatment of some types of cancer. Epothilone ZK2219477 stops the growth of tumor cells by blocking cell division. It is a type of antimitotic agent.

Display Name: Sagopilone

Label: Sagopilone

NCI Thesaurus Code: C61072 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C2355512  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
(1S,3S,7S,10R,11S,12S,16R)-7,11-dihydroxy-8,8,12,16-tetramethyl-3-(2-methyl-1,3-benzothiazol-5-yl)-10-(prop-2-enyl)-4,17-dioxabicyclo(14.1.0)heptadecane-5,9-dione
DE-03757
Epothilone ZK219477
epothilone ZK219477
Sagopilone
SAGOPILONE
SH-Y03757A
ZK-219477
ZK-EPO
ZK-Epothilone

External Source Codes: 
CAS Registry Number 305841-29-6 (see NLM ChemIDplus info)
FDA UNII Code KY72JU32FO
PDQ Closed Trial Search ID 615854
PDQ Open Trial Search ID 615854 (check for NCI PDQ open clinical trial info)
UMLS CUI C2355512

Other Properties:
Name Value (qualifiers indented underneath)
Chemical_Formula C30H41NO6S
code C61072
Contributing_Source CTRP
Contributing_Source FDA
Legacy_Concept_Name ZK219477
Semantic_Type Chemical Viewed Structurally
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C61072

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