|Sagopilone (Code C61072)|
|Terms & Properties|
Preferred Name: Sagopilone
Definition: A fully synthetic low-molecular-weight epothilone with potential antineoplastic activity. Sagopilone binds to tubulin and induces microtubule polymerization while stabilizing microtubules against depolymerization, which may result in the inhibition of cell division, the induction of G2/M arrest, and apoptosis. The agent is not a substrate for the P-glycoprotein (P-gp) efflux pump and so may exhibit activity in multidrug-resistant (MDR) tumors. The epothilone class of metabolites was originally isolated from the myxobacterium Solangium cellulosum.
NCI-GLOSS Definition: A form of the substance epothilone that is made in the laboratory. It is being studied in the treatment of some types of cancer. Epothilone ZK2219477 stops the growth of tumor cells by blocking cell division. It is a type of antimitotic agent.
Display Name: Sagopilone
NCI Metathesaurus Link: C2355512 (see NCI Metathesaurus info)
Synonyms & Abbreviations: (see Synonym Details)
External Source Codes:
|CAS Registry Number||305841-29-6 (see NLM ChemIDplus info)|
|FDA UNII Code||KY72JU32FO|
|PDQ Closed Trial Search ID||615854|
|PDQ Open Trial Search ID||615854 (check for NCI PDQ open clinical trial info)|
|Name||Value (qualifiers indented underneath)|
Additional Concept Data:
|Defined Fully by Roles: No|