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Version: 17.06d (Release date: 2017-06-26)
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Aerosolized Liposomal Rubitecan (Code C61071)

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Terms & Properties

Preferred Name: Aerosolized Liposomal Rubitecan

Definition: An aerosolized liposomal preparation of rubitecan, a water-insoluble derivative of camptothecin with potential antineoplastic activity. Rubitecan (or 9-nitro-20 (S)-camptothecin) and its active metabolite 9-aminocamptothecin (9-AC) selectively stabilize topoisomerase I-DNA covalent complexes during S-phase, thereby inhibiting religation of topoisomerase I-mediated single-strand DNA breaks and producing potentially lethal double-strand DNA breaks when encountered by the DNA replication machinery. This agent is formulated with dilauroylphosphatidylcholine and nebulized in particle sizes of 1.2-1.6 micrometer mass median aerodynamic diameter.

Label: Aerosolized Liposomal Rubitecan

NCI Thesaurus Code: C61071 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C1831773  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Aerosolized liposomal 9-nitro-20(S)-camptothecin
Aerosolized Liposomal Rubitecan

External Source Codes: 
PDQ Closed Trial Search ID 473242
PDQ Open Trial Search ID 473242 (check for NCI PDQ open clinical trial info)
UMLS CUI C1831773

Other Properties:
     Name Value (qualifiers indented underneath)
code C61071
Legacy_Concept_Name Aerosolized_Liposomal_9-Nitrocamptothecin
Semantic_Type Chemical Viewed Functionally

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C61071

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