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Version: 17.08d (Release date: 2017-08-28)
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Intetumumab (Code C61070)

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Terms & Properties

Preferred Name: Intetumumab

Definition: A pan alpha-v human monoclonal antibody that recognizes alpha-v beta-1, alpha-v beta-3, alpha-v beta-5, and alpha-v beta-6 integrins with antiangiogenic and antitumor activities. Intetumumab competitively binds to and blocks both alpha-v beta-3 and alpha-v beta-5 integrins, resulting in inhibition of integrin-mediated tumor angiogenesis and tumor growth. Integrins facilitate the adhesion of stimulated endothelial cells to the extracellular matrix (ECM); trigger the secretion of ECM-rearranging proteases; and propagate signaling events that promote the survival and differentiation of cells in newly formed vasculature.

Display Name: Intetumumab

Label: Intetumumab

NCI Thesaurus Code: C61070 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C1881068  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
CNTO 095
Human Anti-Alpha-5 Integrin Monoclonal Antibody
Human Monoclonal CNTO 95 gamma1 heavy chain (222-215')-disulfide with Human Monoclonal CNTO 95 kappa light chain dimer (228-228'':231-231'')-bisdisulfide
Immunoglobulin G1, anti-(human integrin alpha-V (vitronectin receptor subunit alpha or CD51))

External Source Codes: 
CAS Registry Number 725735-28-4 (see NLM ChemIDplus info)
PDQ Closed Trial Search ID 473196
PDQ Open Trial Search ID 473196 (check for NCI PDQ open clinical trial info)
UMLS CUI C1881068

Other Properties:
     Name Value (qualifiers indented underneath)
code C61070
Contributing_Source CTRP
Contributing_Source FDA
Legacy_Concept_Name Human_Anti-Alpha-5_Integrin_Monoclonal_Antibody
Semantic_Type Amino Acid, Peptide, or Protein

Additional Concept Data: 
Defined Fully by Roles: No  


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