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Version: 16.11d (Release date: 2016-11-28)
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Intetumumab (Code C61070)

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Terms & Properties

Preferred Name: Intetumumab

Definition: A pan alpha-v human monoclonal antibody that recognizes alpha-v beta-1, alpha-v beta-3, alpha-v beta-5, and alpha-v beta-6 integrins with antiangiogenic and antitumor activities. Intetumumab competitively binds to and blocks both alpha-v beta-3 and alpha-v beta-5 integrins, resulting in inhibition of integrin-mediated tumor angiogenesis and tumor growth. Integrins facilitate the adhesion of stimulated endothelial cells to the extracellular matrix (ECM); trigger the secretion of ECM-rearranging proteases; and propagate signaling events that promote the survival and differentiation of cells in newly formed vasculature.

Display Name: Intetumumab

Label: Intetumumab

NCI Thesaurus Code: C61070 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C1881068  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
CNTO-95
CNTO 095
Human Anti-Alpha-5 Integrin Monoclonal Antibody
Human Monoclonal CNTO 95 gamma1 heavy chain (222-215')-disulfide with Human Monoclonal CNTO 95 kappa light chain dimer (228-228'':231-231'')-bisdisulfide
Immunoglobulin G1, anti-(human integrin alpha-V (vitronectin receptor subunit alpha or CD51))
Intetumumab
INTETUMUMAB

External Source Codes: 
CAS Registry Number 725735-28-4 (see NLM ChemIDplus info)
FDA UNII Code GQE1BJE2NI
PDQ Closed Trial Search ID 473196
PDQ Open Trial Search ID 473196 (check for NCI PDQ open clinical trial info)
UMLS CUI C1881068

Other Properties:
Name Value (qualifiers indented underneath)
code C61070
Contributing_Source CTRP
Contributing_Source FDA
Legacy_Concept_Name Human_Anti-Alpha-5_Integrin_Monoclonal_Antibody
Semantic_Type Amino Acid, Peptide, or Protein

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C61070

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