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Version: 17.06d (Release date: 2017-06-26)
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Recombinant Bispecific Single-Chain Antibody rM28 (Code C60882)

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Terms & Properties

Preferred Name: Recombinant Bispecific Single-Chain Antibody rM28

Definition: A recombinant, bispecific, single-chain antibody directed against both the T-cell surface-associated costimulatory molecule CD28 and a melanoma-associated proteoglycan (MAPG) with potential antitumor activity. By targeting both CD28 and MAPG, recombinant bispecific single-chain antibody rM28 enhances cytotoxic T-cell recognition of melanoma cells, which may result in immune effector cell-mediated tumor cell death and a decrease in distant metastases. This agent appears to have a long serum half-life secondary to the formation of dimers. When activated, CD28 facilitates interactions between T-cells and other immune effector cells resulting in cytotoxic T-lymphocyte responses; MAPG is a surface antigen expressed on the majority of melanomas, including primary cutaneous, ocular, and metastatic melanomas.

Label: Recombinant Bispecific Single-Chain Antibody rM28

NCI Thesaurus Code: C60882 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C1831730  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Recombinant Bispecific Single-Chain Antibody rM28
rM28

External Source Codes: 
PDQ Closed Trial Search ID 467183
PDQ Open Trial Search ID 467183 (check for NCI PDQ open clinical trial info)
UMLS CUI C1831730

Other Properties:
     Name Value (qualifiers indented underneath)
code C60882
Legacy_Concept_Name Recombinant_Bispecific_Single-Chain_Antibody_rM28
Semantic_Type Amino Acid, Peptide, or Protein
Semantic_Type Immunologic Factor

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C60882

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