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Version: 17.10e (Release date: 2017-10-30)
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Hypertonic Saline (Code C60814)

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Terms & Properties

Preferred Name: Hypertonic Saline

Definition: Any solution of sodium chloride (NaCl) in water with a concentration of NaCl higher than that found in physiological saline (0.9% w/v). When administered in vivo, hypertonic saline (HTS) exhibits several physiological effects beneficial to cerebral injury including: 1) osmotic and vasoregulatory - by promoting the flow of excess water from cerebral tissue to the blood via osmosis and decreasing edema in the vascular endothelium of injured tissues, thus lowering vascular resistance and allowing more blood flow; 2) hemodynamic - by effectively expanding plasma volume; 3) immunomodulatory - by preventing leukocytes from becoming activated and adhering to injured neurons and; 4) neurochemical - by counteracting detrimental excitatory amino acids through the normalization of neuronal cell membranes and by restoration of normal electrolyte and neurotransmitter levels in brain cells, and normal cell volumes.

Display Name: Hypertonic Saline

Label: Hypertonic Saline

NCI Thesaurus Code: C60814 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0036085  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Hypertonic Saline
Hypertonic Saline Solution

External Source Codes: 
PDQ Closed Trial Search ID 467928
PDQ Open Trial Search ID 467928 (check for NCI PDQ open clinical trial info)
UMLS CUI C0036085

Other Properties:
     Name Value (qualifiers indented underneath)
code C60814
Contributing_Source CTRP
Legacy_Concept_Name Hypertonic_Saline
Semantic_Type Inorganic Chemical
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  


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