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Version: 16.11d (Release date: 2016-11-28)
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Tinzaparin Sodium (Code C60810)

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Terms & Properties

Preferred Name: Tinzaparin Sodium

Definition: The sodium salt of a low molecular weight heparin (LMWH), obtained by controlled enzymatic depolymerization of heparin from porcine intestinal mucosa, with antithrombotic properties. Tinzaparin is a potent inhibitor of several activated coagulation factors, especially Factors Xa and IIa (thrombin); its primary activity is mediated through the plasma protease inhibitor antithrombin. In addition, this agent may inhibit angiogenesis through: 1) competitive binding of the heparin-binding sites on endothelial cells for the proangiogenic cytokines vascular endothelial growth factor (VEGF) and beta-fibroblast growth factor (beta-FGF) and 2) increasing the release of tissue factor pathway inhibitor (TFPI), a negative regulator of angiogenesis.

NCI-GLOSS Definition: A drug that is used with another drug, warfarin, to treat blood clots that form deep in the veins and to prevent new blood clots from forming. It is a type of anticoagulant.

Display Name: Tinzaparin Sodium

Label: Tinzaparin Sodium

NCI Thesaurus Code: C60810 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0354599  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Enzyme Depolymerized Heparin (MW 6500)
Inno-hep
Innohep
LNH-1
Logiparin
Tinzaparin
Tinzaparin Sodium
TINZAPARIN SODIUM
tinzaparin sodium
Tinzaparin Sodium Injection

External Source Codes: 
CAS Registry Number 9041-08-1 (see NLM ChemIDplus info)
FDA UNII Code 3S182ET3UA
PDQ Closed Trial Search ID 467737
PDQ Open Trial Search ID 467737 (check for NCI PDQ open clinical trial info)
UMLS CUI C0354599

Other Properties:
Name Value (qualifiers indented underneath)
Accepted_Therapeutic_Use_For Treatment of acute symptomatic deep venous thrombosis (DVT) with or without a pulmonary embolism (PE), in conjunction with warfarin.
Chemical_Formula (C14H18NO11)n.2(C12H15NO13S)n.3Na.3O3S
code C60810
Contributing_Source CTRP
Contributing_Source FDA
Legacy_Concept_Name Tinzaparin
Semantic_Type Organic Chemical
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C60810

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