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Version: 17.12d (Release date: 2017-12-26)
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Tinzaparin Sodium (Code C60810)

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Terms & Properties

Preferred Name: Tinzaparin Sodium

Definition: The sodium salt of a low molecular weight heparin (LMWH), obtained by controlled enzymatic depolymerization of heparin from porcine intestinal mucosa, with antithrombotic properties. Tinzaparin is a potent inhibitor of several activated coagulation factors, especially Factors Xa and IIa (thrombin); its primary activity is mediated through the plasma protease inhibitor antithrombin. In addition, this agent may inhibit angiogenesis through: 1) competitive binding of the heparin-binding sites on endothelial cells for the proangiogenic cytokines vascular endothelial growth factor (VEGF) and beta-fibroblast growth factor (beta-FGF) and 2) increasing the release of tissue factor pathway inhibitor (TFPI), a negative regulator of angiogenesis.

NCI-GLOSS Definition: A drug that is used with another drug, warfarin, to treat blood clots that form deep in the veins and to prevent new blood clots from forming. It is a type of anticoagulant.

Display Name: Tinzaparin Sodium

Label: Tinzaparin Sodium

NCI Thesaurus Code: C60810 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0354599  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Enzyme Depolymerized Heparin (MW 6500)
Tinzaparin Sodium
tinzaparin sodium
Tinzaparin Sodium Injection

External Source Codes: 
CAS Registry Number 9041-08-1 (see NLM ChemIDplus info)
PDQ Closed Trial Search ID 467737
PDQ Open Trial Search ID 467737 (check for NCI PDQ open clinical trial info)
UMLS CUI C0354599

Other Properties:
     Name Value (qualifiers indented underneath)
Accepted_Therapeutic_Use_For Treatment of acute symptomatic deep venous thrombosis (DVT) with or without a pulmonary embolism (PE), in conjunction with warfarin.
Chemical_Formula (C14H18NO11)n.2(C12H15NO13S)n.3Na.3O3S
code C60810
Contributing_Source CTRP
Contributing_Source FDA
Legacy_Concept_Name Tinzaparin
Semantic_Type Organic Chemical
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  


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