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Version: 17.06d (Release date: 2017-06-26)
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Pazopanib Hydrochloride (Code C60779)

Terms & Properties Synonym Details Relationships Mapping View All  
Terms & Properties

Preferred Name: Pazopanib Hydrochloride

Definition: The hydrochloride salt of a small molecule inhibitor of multiple protein tyrosine kinases with potential antineoplastic activity. Pazopanib selectively inhibits vascular endothelial growth factor receptors (VEGFR)-1, -2 and -3, c-kit and platelet derived growth factor receptor (PDGF-R), which may result in inhibition of angiogenesis in tumors in which these receptors are upregulated.

NCI-GLOSS Definition: A drug that is used to treat kidney cancer and is being studied in the treatment of other types of cancer. It may prevent the growth of new blood vessels that tumors need to grow. It is a type of protein tyrosine kinase inhibitor and a type of antiangiogenesis agent.

Display Name: Pazopanib Hydrochloride

Label: Pazopanib Hydrochloride

NCI Thesaurus Code: C60779 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C1872226  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
5-((4-((2,3-Dimethyl-2h-Indazol-6-Yl)Methylamino)Pyrimidin-2-yl)Amino)-2-Methylbenzenesulfonamide Monohydrochloride
GW786034B
Pazopanib Hydrochloride
pazopanib hydrochloride
PAZOPANIB HYDROCHLORIDE
Votrient

External Source Codes: 
CAS Registry Number 635702-64-6 (see NLM ChemIDplus info)
FDA UNII Code 33Y9ANM545
NSC Code 737754 (see NCI DTP info)
PDQ Closed Trial Search ID 476479
PDQ Open Trial Search ID 476479 (check for NCI PDQ open clinical trial info)
UMLS CUI C1872226

Other Properties:
     Name Value (qualifiers indented underneath)
Chemical_Formula C21H23N7O2S.HCl
code C60779
Contributing_Source CTRP
Contributing_Source FDA
Legacy_Concept_Name Pazopanib
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C60779

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