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Version: 16.10e (Release date: 2016-10-31)
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Wild-type Reovirus (Code C60774)

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Terms & Properties

Preferred Name: Wild-type Reovirus

Definition: A serotype 3 Dearing strain (T3D) of reovirus (Respiratory Enteric Orphan VIRUS). Reovirus, a dsRNA virus, is able to replicate specifically in cancer cells bearing an activated Ras pathway. In contrast to normal cells, two-thirds of human cancer cells are Ras-activated, and are deficient in their ability to trigger the antiviral response mediated by the host cellular protein, double-stranded RNA-dependent protein kinase (PKR). In Ras-activated cancer cells, reovirus is able to freely replicate and subsequently cause apoptosis in the tumor cells. Cell lysis frees progeny viral particles to infect surrounding cancer cells. This cycle of infection, replication and cell death is believed to be repeated until no more Ras-activated tumor cells are available. Because the reovirus kills Ras-activated cancer cells, this is a potential therapeutic for malignant glioma, pancreatic, colon and some lung cancers.

Display Name: Wild-type Reovirus

Label: Wild-type Reovirus

NCI Thesaurus Code: C60774 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C1882931  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Reolysin
Wild-type Reovirus

External Source Codes: 
NSC Code 729968 (see NCI DTP info)
PDQ Closed Trial Search ID 563224
PDQ Open Trial Search ID 563224 (check for NCI PDQ open clinical trial info)
UMLS CUI C1882931

Other Properties:
Name Value (qualifiers indented underneath)
code C60774
Contributing_Source CTRP
Legacy_Concept_Name Reolysin
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C60774

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