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Version: 17.06d (Release date: 2017-06-26)
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Veliparib (Code C60768)

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Terms & Properties

Preferred Name: Veliparib

Definition: A poly(ADP-ribose) polymerase (PARP) -1 and -2 inhibitor with chemosensitizing and antitumor activities. With no antiproliferative effects as a single agent at therapeutic concentrations, ABT-888 inhibits PARPs, thereby inhibiting DNA repair and potentiating the cytotoxicity of DNA-damaging agents. PARP nuclear enzymes are activated by DNA single or double strand breaks, resulting in the poly(ADP-ribosyl)ation of other nuclear DNA binding proteins involved in DNA repair; poly(ADP-ribosyl)ation contributes to efficient DNA repair and to survival of proliferating cells exposed to mild genotoxic stresses as induced by as oxidants, alkylating agents or ionizing radiation.

NCI-GLOSS Definition: A substance being studied in the treatment of breast cancers caused by mutations (changes) in the BRCA1 and BRCA2 genes. It is also being studied in the treatment of other types of cancer. It blocks an enzyme involved in many functions of the cell, including the repair of DNA damage. DNA damage may be caused by normal cell actions, UV light, some anticancer drugs, and radiation used to treat cancer. ABT-888 may cause cancer cells to die. It is a type of poly(ADP-ribose) polymerase inhibitor.

Display Name: Veliparib

Label: Veliparib

NCI Thesaurus Code: C60768 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C1958300  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
2-((R)-2-Methylpyrrolidin-2-yl)-1H-benzimidazole-4-carboxamide
ABT-888
PARP-1 inhibitor ABT-888
Veliparib
VELIPARIB
veliparib

External Source Codes: 
CAS Registry Number 912444-00-9 (see NLM ChemIDplus info)
FDA UNII Code 01O4K0631N
ChEBI ID CHEBI:62880 (see ChEBI info)
NSC Code 737664 (see NCI DTP info)
PDQ Closed Trial Search ID 496464
PDQ Open Trial Search ID 496464 (check for NCI PDQ open clinical trial info)
UMLS CUI C1958300

Other Properties:
     Name Value (qualifiers indented underneath)
Chemical_Formula C13H16N4O
code C60768
Contributing_Source CTRP
Contributing_Source FDA
Legacy_Concept_Name ABT-888
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C60768

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