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Version: 17.12d (Release date: 2017-12-26)
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Indium In 111 CHX-A DTPA Trastuzumab (Code C60766)

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Terms & Properties

Preferred Name: Indium In 111 CHX-A DTPA Trastuzumab

Definition: An indium In 111-labeled trastuzumab with potential use as an imaging agent. Indium In 111 CHX-A DTPA trastuzumab is chemically conjugated via a bifunctional metal chelator molecule, 2-(p-isothiocyanatobenzyl)-cyclohexyl-diethylenetriaminepentaacetic acid (CHX-A DTPA), a backbone-substituted derivative of DTPA. This agent may allow radioimmunolocalization of HER2-positive cells. Trastuzumab, a recombinant humanized monoclonal antibody that selectively binds with high affinity to the extracellular domain of human epidermal growth factor receptor 2 (HER2), may elicit an antibody-dependent cellular cytotoxicity (ADCC) against tumor cells that overexpress HER2.

NCI-GLOSS Definition: A substance being studied in the imaging of breast cancer and some other types of cancer. It is made by attaching a radioactive substance called indium 111 to the monoclonal antibody trastuzumab (Herceptin). Trastuzumab binds to the human growth factor receptor 2 (HER2/neu) on some breast cancer cells and on several other types of cancer cells. Indium In 111 CHX-A DTPA trastuzumab is a type of radioimmunoconjugate.

Display Name: Indium In 111 CHX-A DTPA Trastuzumab

Label: Indium In 111 CHX-A DTPA Trastuzumab

NCI Thesaurus Code: C60766 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: CL360663  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Indium In 111 CHX-A DTPA Trastuzumab
indium In 111 CHX-A DTPA trastuzumab

External Source Codes: 
NSC Code 740377 (see NCI DTP info)
PDQ Closed Trial Search ID 543723
PDQ Open Trial Search ID 543723 (check for NCI PDQ open clinical trial info)

Other Properties:
     Name Value (qualifiers indented underneath)
code C60766
Contributing_Source CTRP
Legacy_Concept_Name Indium-CHX-A_DTPA-Trastuzumab
Semantic_Type Amino Acid, Peptide, or Protein
Semantic_Type Indicator, Reagent, or Diagnostic Aid

Additional Concept Data: 
Defined Fully by Roles: No  


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