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Leucovorin Calcium (Code C607)

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Terms & Properties

Preferred Name: Leucovorin Calcium

Definition: An active metabolite of folic acid (also called folinic acid and citrovorum factor), which does not require metabolism by dihydrofolate reductase, the molecular target of folate antagonist-type chemotherapeutic drugs. Leucovorin calcium counteracts the toxic effects of these medications, 'rescuing' the patient while permitting the antitumor activity of the folate antagonist. This agent also potentiates the effects of fluorouracil and its derivatives by stabilizing the binding of the drug's metabolite to its target enzyme, thus prolonging drug activity. (NCI04)

NCI-GLOSS Definition: A drug used to lessen the toxic effects of substances that block the action of folic acid, especially the anticancer drug methotrexate. Leucovorin calcium is used to treat some types of anemia and is also used with fluorouracil to treat colorectal cancer. It is also being studied in the treatment of other types of cancer and other conditions. Leucovorin calcium is a form of folic acid. It is a type of chemoprotective agent and a type of chemosensitizing agent.

Display Name: Leucovorin Calcium

Label: Leucovorin Calcium

NCI Thesaurus Code: C607 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0731033  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
5-Formyl-5,6,7,8-tetrahydrofolic Acid
5-Formyl-5,6,7,8-tetrahydropteroyl-L-glutamic Acid
5-Formyl Tetrahydrofolate
Adinepar
Calcifolin
Calcium (6S)-Folinate
Calcium Folinate
Calcium Leucovorin
Calcium N-(p-((((6RS)-2-amino-5-formyl-5,6,7,8-tetrahydro-4-hydroxy-6-pteridinyl)methyl)amino)benzoyl)-L-glutamate (1:1)
Calfolex
Calinat
Cehafolin
Citofolin
Citrec
Citrovorum Factor
citrovorum factor
Cromatonbic Folinico
Dalisol
Disintox
Divical
Ecofol
Emovis
Factor, Citrovorum
Flynoken A
Folaren
Folaxin
FOLI-cell
Foliben
Folidan
Folidar
Folinac
Folinate Calcium
folinic acid
Folinic Acid Calcium Salt Pentahydrate
Folinoral
Folinvit
Foliplus
Folix
Fusilev
Imo
Lederfolat
Lederfolin
Leucosar
leucovorin
Leucovorin Calcium
leucovorin calcium
LEUCOVORIN CALCIUM
N-[4-[[(2-Amino-5-formyl-1,4,5,6,7,8-hexahydro-4-oxo-6-pteridinyl)methyl]amnio]benzoyl]-L-glutamic Acid, Calcium Salt (1:1)
N-[p-[[(2-Amino-5-formyl-5,6,7,8-tetrahydro-4-hydroxy-6-pteridinyl)methyl]amino]benzoyl]glutamic Acid
Rescufolin
Rescuvolin
Tonofolin
Wellcovorin

External Source Codes: 
CAS Registry Number 1492-18-8 (see NLM ChemIDplus info)
FDA UNII Code RPR1R4C0P4
NSC Code 3590 (see NCI DTP info)
PDQ Closed Trial Search ID 42584
PDQ Open Trial Search ID 42584 (check for NCI PDQ open clinical trial info)
UMLS CUI C0731033

Other Properties:
     Name Value (qualifiers indented underneath)
Accepted_Therapeutic_Use_For Megaloblastic anemia due to folate deficiency; Enhanced fluorouracil inhibition of thymidylate synthase; Reverse dihydrofolate reductase inhibition by methotrexate; Folic acid antagonist overdose; Nitrous Oxide toxicity
code C607
Contributing_Source CTRP
Contributing_Source FDA
Legacy_Concept_Name Leucovorin_Calcium
Semantic_Type Organic Chemical
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C607

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