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Version: 16.11d (Release date: 2016-11-28)
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Ketoconazole (Code C605)

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Terms & Properties

Preferred Name: Ketoconazole

Definition: A synthetic derivative of phenylpiperazine with broad antifungal properties and potential antineoplastic activity. Ketoconazole inhibits sterol 14-a-dimethylase, a microsomal cytochrome P450-dependent enzyme, thereby disrupting synthesis of ergosterol, an important component of the fungal cell wall. (NCI04)

NCI-GLOSS Definition: A drug that treats infection caused by a fungus. It is also used as a treatment for prostate cancer because it can block the production of male sex hormones.

Display Name: Ketoconazole

Label: Ketoconazole

NCI Thesaurus Code: C605 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0022625  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Cis-1-Acetyl-4-[4-[[2-(2,4-dichlorophenyl)-2-(1H-imidazole-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]piperazine
Fungarest
Fungoral
Ketoconazole
KETOCONAZOLE
ketoconazole
Ketoderm
Ketoisdin
Nizoral
Orifungal M
Panfungol
R-41400
Xolegel

External Source Codes: 
CAS Registry Number 65277-42-1 (see NLM ChemIDplus info)
FDA UNII Code R9400W927I
ChEBI ID CHEBI:47519 (see ChEBI info)
NSC Code 317629 (see NCI DTP info)
PDQ Closed Trial Search ID 39488
PDQ Open Trial Search ID 39488 (check for NCI PDQ open clinical trial info)
UMLS CUI C0022625

Other Properties:
Name Value (qualifiers indented underneath)
Accepted_Therapeutic_Use_For Seborrheic Dermatitis; Prostate cancer
Chemical_Formula C26H28Cl2N4O4
code C605
Contributing_Source CTRP
Contributing_Source FDA
Legacy_Concept_Name Ketoconazole
Semantic_Type Antibiotic
Semantic_Type Organic Chemical

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C605

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