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Version: 17.06d (Release date: 2017-06-26)
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Isotretinoin (Code C603)

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Terms & Properties

Preferred Name: Isotretinoin

Definition: A naturally-occurring retinoic acid with potential antineoplastic activity. Isotretinoin binds to and activates nuclear retinoic acid receptors (RARs); activated RARs serve as transcription factors that promote cell differentiation and apoptosis. This agent also exhibits immunomodulatory and anti-inflammatory responses and inhibits ornithine decarboxylase, thereby decreasing polyamine synthesis and keratinization.

NCI-GLOSS Definition: A drug that is used in the treatment of acne and psoriasis and is being studied in cancer prevention. It is a type of retinoid.

Display Name: Isotretinoin

Label: Isotretinoin

NCI Thesaurus Code: C603 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0022265  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
13-cis-Retinoate
13-cis-Retinoic Acid
13-cis-Vitamin A Acid
13-cis retinoic acid
13-cRA
3,7-Dimethyl-9-(2,6,6-trimethyl-1-cyclohexen-1-yl)2-cis-4-trans-6-trans-8-trans-nonatetraenoic Acid
Accure
Accutane
Amnesteem
cis-Retinoic Acid
Cistane
Claravis
Isotretinoin
ISOTRETINOIN
isotretinoin
Isotretinoinum
Isotrex
Isotrexin
Neovitamin A
Neovitamin A Acid
Oratane
Retinoicacid-13-cis
Ro-4-3780
Roaccutan
Roaccutane
Roacutan
Ro 4-3780
Sotret

External Source Codes: 
CAS Registry Number 4759-48-2 (see NLM ChemIDplus info)
FDA UNII Code EH28UP18IF
ChEBI ID CHEBI:6067 (see ChEBI info)
NSC Code 329481 (see NCI DTP info)
PDQ Closed Trial Search ID 42657
PDQ Open Trial Search ID 42657 (check for NCI PDQ open clinical trial info)
UMLS CUI C0022265

Other Properties:
     Name Value (qualifiers indented underneath)
Accepted_Therapeutic_Use_For Severe recalcitrant nodular acne; psoriasis; cornification disorders; cutaneous T-cell lymphoma; juvenile metastatic neuroblastoma and leukemia
Chemical_Formula C20H28O2
code C603
Contributing_Source CTRP
Contributing_Source FDA
Legacy_Concept_Name Isotretinoin
Semantic_Type Organic Chemical
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C603

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